Man airlifted to hospital after M1 crash
The southbound carriageway remains closed between junction 32 at Thurcroft and junction 31 at Aston.
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Hide AdThe incident also led to the M18 being closed between junction 1 at Bramley and junction 32 of the M1 but has now reopened.
A Yorkshire Air Ambulance spokeswoman confirmed its crews attended the incident and airlifted a lorry driver, aged in his 50s, to Northern General Hospital in Sheffield.
She said there were several casualties but others who were injured were taken to hospital by road ambulance.
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Hide AdTraffic remains extremely heavy on the two motorways and surrounding routes in Aston, Bramley and Whiston.
Motorists have been told to expect delays.
Earlier reports suggested the accident involved three cars and a lorry.