Millers need a favour
A win would lift them eight points clear of Rotherham with only seven games to play, making them even harder to catch.
And while manager Steve Evans' immediate priority is securing a play-off place, he knows that if the Blades can pull off an upset tonight then it will offer his players extra encouragement for the final games.
He said: "I just hope Sheffield United are good enough to beat a quality side like Brentford. I'm not sure they are — and that's not taking anything away from what Nigel Clough has achieved there — but if they do win then I'll be the first to acclaim them.
"I'll be sat there watching it and I'll be kicking and heading every ball for them."
The Blades' loss to Swindon at the weekend hit their already slim hopes of reaching the play-offs.
Evans added: "I wish they'd won because I would much rather we have two South Yorkshire clubs fighting at the top end of the table."