Cohen Bramall the latest injury worry for Rotherham United
Left-back Cohen Bramall had to come off late on Wednesday night's home loss to Bristol City and may struggle to be available for the Millers' first-ever match at St Mary's Stadium against opposition who were a Premier League outfit last season.
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Hide AdThe 27-year-old hurt his knee in a Yorkshire derby at John Smith's Stadium three weeks ago but has managed to continue playing.
Speaking after the stoppage-time 2-1 defeat at the hands of the Robins, manager Matt Taylor said: "It might be a hangover issue after Huddersfield Town. It was a collision rather than a muscular problem. It remains to be seen if he will be fit."
Rotherham head to Southampton without regular centre-halves Cameron Humphreys and Tyler Blackett, who both have hamstring issues, and a third central defender, Sean Morrison, is sidelined with a calf complaint.
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Hide AdThe Millers may be forced to pair Grant Gall and right-back together at the heart of the backline even though both have only just returned after long absences caused by calf and hamstring problems respectively.
Taylor's men are in next-to-bottom spot after one win in ten matches and they have lost every away game so far this term.
The boss, who is also lacking the services of midfielders Hakeem Odoffin and Jamie Lindsay and winger Shane Ferguson, highlighted the difficulties he and his squad are facing after they were hit by a 96th-minute winner on Wednesday.
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Hide Ad"The players have to keep finding a way to believe they are good enough when the results right now are telling us we are not," he said.
"For large parts of the game against a good Bristol City team, we showed we are good enough. We have shown it this season and will keep on showing it.
"But how we withstand all the pressure of all these injuries, I have not got the answers to those questions as yet; even more so when the people affected are influential players in important positions."
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Hide AdAfter four straight defeats, Southampton have won their last two games, beating Leeds United at home last Saturday then triumphing 1-0 at Stoke City on Tuesday.
The Millers, who are today making the long journey south for an overnight stay, have had 24 hour less to prepare than the Saints as they played a day later in midweek.